People's Daily Online's algorithm recommendation has not been a booster for spreading low-level doubts_亚洲体育下注投注站
The long thoughtfulness of night....
Captured the City of the Yellow Dragon.
The evaluation of the fall and revival of the plot of capital to the countryside did not replace the fellow
It's a long way home, a long way east.
As the merits of 996 schedule was obviously overshadowed by its disadvantages, I, as an potential employee in the future, would probably not take a job with such a schedule, unless the job appeals to me to the extent that I would like to work overtime voluntarily. As afore-mentioned, excessively extended working schedule not only deprives workers of their legitimate rights and interests but also drains their energy and creativity. Then why should we, employees, be under long-term pain to trade for employer’s short-term gain?
In the host of the National Natural Science Foundation's key project "Integrated PK/PD and Metabolomics of Huanglian Jiedu Decoction in the basic research of pharmacodynamics," the authors found that the energy metabolism of septic rats changed from oxidative phosphorylation to aerobic sugar. Fermentation confirms that aerobic glycolysis plays an important role in the development of inflammation. 4-octyl itaconic acid (4-OI) is a derivative of the small molecule metabolite itaconic acid, having the structure of an α,β-unsaturated ketone, which can alkylate the sulfhydryl group on the protein. The results of protein mass spectrometry showed that 4-OI directly acts on the 22nd position of the cysteine residue on GAPDH, and inhibited its enzyme activity and reduced the release of inflammatory factors. Metabolic flow experiments showed that 4-OI blocked glycolysis at GAPDH, decreased extracellular acidification rate, and increased intracellular oxygen consumption. Further BMDM cells knocked out by Irg1 showed reduced endogenous itaconic acid production, which increased the rate of glycolysis and the release of disease factors. In animal models, it was further confirmed that 4-OI is effective in inhibiting inflammation. This study provides novel insights into the regulation of 4-OI-mediated metabolic reprogramming and highlights the importance of targeting aerobic glycolysis in the treatment of inflammatory diseases, which provides new ideas for the development of new anti-inflammatory drugs in the future.