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"The task is going to be difficult because we have an opponent that are the reigning champions," said Atletico director Clemente Villaverde.
Depay has scored eight times in his last eight matches in all competitions for Lyon, including the goal that took them to the last 16 of the Champions League midweek.
Martin Montoya and Yves Bissouma came in for Brighton, with Dale Stephens suspended, and Steven Alzate dropped to the bench.
Jurgen Klopp's side will travel to the Wanda Metropolitano, where Liverpool lifted the trophy in June, for the first leg of their tie against three-time runners-up Atletico.
"I understand that our tennis era is changing in a way, the top-three are getting older obviously, we are the ones come from behind. So for me, I do have as a goal to win a Grand Slam title next year, that's for sure, but it's not a matter of life or death for me," explained Tsitsipas, who takes on Andrey Rublev in Abu Dhabi on Thursday, with the winner moving on to play Djokovic on Friday.
Palace have now moved above London rivals Arsenal in the table and Zaha was proud of the way his side stayed in the game against a Brighton team who had much the better of the play.
A large-scale safety operation will be deployed around the match involving 3,000 security personnel while both teams have been instructed to travel to the stadium from the same hotel.
The Ukraine forward wrote an open letter to Rayo's supporters denying any links to neo-Nazi groups but some fans still attended his first training session with a banner that read Vallecas was "not a place for Nazis."
Zozulya joined Rayo on loan in 2017 from Real Betis but never made an appearance for the club after his spell was
Wilfried Zaha's equalizer lifted Crystal Palace up to ninth in the Premier League table as they shared the points in a 1-1 draw at home to Brighton on Monday.
Van Bommel, one of the stars of the Dutch team that ended as runners-up in the 2010 World Cup, was in his second season as manager of PSV.
The Boro were fourth back on Christmas Day of the 1998-99 season, but that seeems a long way back for their long-suffering fans. They were relegated in 2017 despite reaching the UEFA Cup Final of 2006. Currently near the top of the Championship under former defender Jonathan Woodgate.
Only six clubs have won the English Premier League since its inception in the 1992-93 season: Manchester United, Arsenal, Chelsea, Manchester City, Blackburn Rovers and Leicester City.
Japan's 2011 FIFA Women's World Cup-winning team will kick off the 2020 Tokyo Olympic torch relay in Fukushima, the area devastated by a tsunami, earthquake and nuclear meltdown eight years ago.
The one team who want Liverpool's record to carry on more than any other, the Toffees were fourth at Christmas in both 2002-03 and 2004-05 under David Moyes. The Scotsman left to replace Sir Alex Ferguson at Manchester United in 2013 and Everton have struggled since. Having just sacked Marco Silva despite a summer of investment, ex- striker Duncan Ferguson is caretaker boss as they look for a new manager.
"I've seen one of PSV's best matches of the season. It's only the result that's been bad," the 42-year-old former Barcelona and Bayern Munich midfielder said.
On Tuesday, they paid a visit to Canada House, in London, to thank officials for the hospitality shown to them while they were there.
"It is therefore obvious to us that the restructure decision must be withdrawn and the court case settled with us first," he said.
Whatever happens this weekend Liverpool find themselves top of the table at the festive season, a place where they have been before. The deja vu is fresh as they were top of the table under Juergen Klopp this time last year.
All eyes will be on the Tottenham Hotspur Stadium, though, where Spurs will aim to continue their revival under Mourinho.
On a dreadful day for Lyon, Depay's teammate Jeff Reine-Adelaide is also out for the season after tearing the same ligament in his right knee.