High above, from a jade chamber, songs float half-way to heaven,_诚信彩专业平台
We have watched the green graves change to snow
Petals of spring fly all through the city
And the moon shone high on the Palace Beyond Time,
A SPRING VIEW
In the host of the National Natural Science Foundation's key project "Integrated PK/PD and Metabolomics of Huanglian Jiedu Decoction in the basic research of pharmacodynamics," the authors found that the energy metabolism of septic rats changed from oxidative phosphorylation to aerobic sugar. Fermentation confirms that aerobic glycolysis plays an important role in the development of inflammation. 4-octyl itaconic acid (4-OI) is a derivative of the small molecule metabolite itaconic acid, having the structure of an α,β-unsaturated ketone, which can alkylate the sulfhydryl group on the protein. The results of protein mass spectrometry showed that 4-OI directly acts on the 22nd position of the cysteine residue on GAPDH, and inhibited its enzyme activity and reduced the release of inflammatory factors. Metabolic flow experiments showed that 4-OI blocked glycolysis at GAPDH, decreased extracellular acidification rate, and increased intracellular oxygen consumption. Further BMDM cells knocked out by Irg1 showed reduced endogenous itaconic acid production, which increased the rate of glycolysis and the release of disease factors. In animal models, it was further confirmed that 4-OI is effective in inhibiting inflammation. This study provides novel insights into the regulation of 4-OI-mediated metabolic reprogramming and highlights the importance of targeting aerobic glycolysis in the treatment of inflammatory diseases, which provides new ideas for the development of new anti-inflammatory drugs in the future.
"The organizers received an alert at 10:08 and dispatched a medical helicopter that reached the biker at 10:16 and found him unconscious after going into cardiac arrest," a statement on the rally's official website reported. "Following resuscitation efforts in situ, the competitor was taken by helicopter to Layla Hospital, where he was sadly pronounced dead."
With no wind stirring my lone sail.